effects of 2-alkylamino-substituted dihydropyridines on rabbit jejunum

in order to investigate the effects of dimethylamino substituent at postion 2 of the dihydropyridine nucleus on its activity, dialkyl 1,4-dihydro-2-[2-(dimethy- lamino) ethyl]-6-methyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyrdinedicar- boxylates (6a-f) were synthesized. the synthesis was started from dialkyl 1,4- dihydro-2,6-dimethyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicar- boxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously. rabbit jejunum was used to determine the relaxant or antagonistic activity of the synthesized compounds. some of the compounds (6c-e) inhibited the spontaneous contractile activity of jejunum, dose-dependently and completely, while high-k+ contracted tissues were relaxed partially.